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Summary

My research assesses human exposure to chemicals and resulting health risks with various models. I believe by developing these models we can highlight chemicals that could result in significant health risks and provide insights for decision-makers to allocate resources to safeguard the health of our society more efficiently. I am especially interested in using physiologically based pharmacokinetic models to explore the link between external exposures and internal doses. My past and current focus is on nanoparticles and chemicals in consumer products. I am also involved in the development and practice of Life Cycle Impact Assessment, which considers the whole life cycle - raw material extraction, manufacturing, packaging, transportation, use, and disposal - of products and evaluates the associated impacts.

Research interests

• Exposure Assessment
• Risk Assessment
• Life Cycle Assessment
• Physiologically Based Pharmacokinetic Modeling

Publications

• Li, D.; Suh, S. Health risks of chemicals in consumer products - a review. Environ. Int. 2019, 123, 580-587. doi: 10.1016/j.envint.2018.12.033
• Fantke, P.; Alyward, L.; Bare, J.; Brown, R.; Chiu, W.; Dodson, R.; Dwyer, R.; Ernstoff, A.; Howard, B.; Jantunen, M.; Jolliet, O.; Judson, R.; Kirchhübel, N.; Li, D.; Miller, A.; Paoli, G.; Price, P.; Rhomberg, L.; Shen, B.; Shin, H.; Teeguarden, J.; Vallero, D.; Wambaugh, J.; Wetmore, B.; Zaleski, R.; McKone, T. Advancements in Life Cycle Human Exposure and Toxicity Characterization. Environ. Health Perspect. 2018, 126, 125001. doi: 10.1289/EHP3871
• Tao, M.; Li, D.; Song, R.; Suh, S.; Keller, A.A. Framework for modeling the release of chemicals from the use of consumer products. Environ. Pollut. 2018, 234, 751-761
  doi: 10.1016/j.envpol.2017.11.058
• Li, D.; Suh, S. Health risks of chemicals in consumer products - a review. Environ. Health Perspect. 2017 (under review).
• Tao, M.; Li, D.; Song, R.; Suh, S.; Keller, A.A. Framework for modeling the release of chemicals from the use of consumer products. Environ. Pollut. 2017 (under review).
• Tsang, M.; Li, D.; Garner, K.L.; Keller, A.A.; Suh, S.; Sonnemann, G.W. Human health impacts of indoor nanomaterial emissions for life cycle assessment: A case-study of titanium dioxide. Environ. Sci. Nano. 2017 (accepted).doi: 10.1039/C7EN00251C
• Fatouraie, M.; Eagle, E.; Li, D.; Morishita, M.; Barres, J.; Wagner, J.G.; Jolliet, O.; Wooldridg, M. Combustion synthesis of CeO2 nanoparticles for aging and inhalation exposure studies. J. Aerosol Sci. 2017, 106, 24-33.doi: 10.1016/j.jaerosci.2016.12.004
• Li, D.; Morishita, M.; Wagner, J.G.; Fatouraie, M.; Wooldridge, M.; Eagle, E.; Barres, J.; Carlander, U.; Emond, C.; Jolliet, O. In vitro biodistribution and physiologically based pharmacokinetic modeling of inhaled fresh and aged cerium oxide nanoparticles. Part. Fibre Toxicol. 2016, 13, 45.doi: 10.1186/s12989-016-0156-2
• Carlander, U.; Li, D.; Jolliet, O.; Emond, C.; Johanson, G. Towards a general physiologically based pharmacokinetic (PBPK) model for intravenously injected nanoparticles. Int. J. Nanomed.2016, 11, 625-640.doi: 10.2147/IJN.S94370
• Hodas, N.; Loh, M.; Shin, H.; Li, D.; Bennett, D.; McKone, T.E.; Jolliet, O.; Weshler, C.J.; Jantunen, M.; Lioy, P.; Fantke, P. Indoor inhalation intake fractions of fine particulate matter: Review of influencing factors. Indoor Air. 2015.doi: 10.1111/ina.12268.
• Li, D.; Huijbregts, M.; Jolliet, O. Life cycle health impacts of polycyclic aromatic hydrocarbon for source-specific mixtures. Int. J. Life Cycle Ass. 2015, 20, 87-99.doi: 10.1007/s11367-014-0810-6
• Li, D.; Johanson, G.; Emond, C.; Carlander, U.; Philbert, M.; Jolliet, O. Physiologically based pharmacokinetic modeling of polyethylene glycol-coated polyacrylamide nanoparticle in rats. Nanotoxicology 2014, 8(S1), 128-137.doi: 10.3109/17435390.2013.863406
• Li, D.; Emond, C.; Johanson, G.; Jolliet, O. Using a PBPK model to study the influence of different characteristics of nanoparticles on their biodistribution. J. Phys.: Conf. Ser. 2013, 429 012019.doi: 10.1088/1742-6596/429/1/012019
• Wenger, Y.; Li, D.; Jolliet, O. Indoor intake fraction and surface sorption of air organic compounds for life cycle assessment. Int. J. Life Cycle Ass. 2012, 17(7), 919-931.doi: 10.1007/s11367-012-0420-0
• Wu, B.; Liu, Z.; Xu, Y.; Li, D.; Li, M. Combined toxicity of cadmium and lead on the earthworm Eisenia fetida (Annelida, Oligochaeta). Ecotox. Environ. Safe. 2012, 81, 122-126.doi: 10.1007/s11367-012-0420-0
• Rosenbaum, R.; Huijbregts, M.; Henderson, A.; Margni, M.; McKone, T.; van de Meent, D.; Hauschild, M.; Shaked, S.; Li, D.; Gold, L.; Jolliet, O. USEtox human exposure and toxicity factors for comparative assessment of toxic emissions in life cycle analysis: sensitivity to key chemical properties. Int. J. Life Cycle Ass. 2011, 16, 710-727.doi: 10.1007/s11367-011-0316-4
• Li, D.; Liu, Z. T.; Cui, Y.B.; Li, W. L.; Fang, Hao.; Li, M.; Kong, Z.M. Toxicity of cyanobacterial bloom extract from Taihu Lake on mouse, Mus musculus. Ecotoxicology 2011, 20(5), 1018-1025.doi: 10.1007/s10646-011-0693-2
• Hu, C.W.; Li, M.; Cui, Y.B.; Li, D.; Chen, J.; Yang, L.Y. Toxicological effects of TiO2 and ZnO nanoparticles in soil on earthworm Eisenia fetida. Soil Biol. Biochem. 2010, 42(4), 586-591. doi: 10.1016/j.soilbio.2009.12.007
• Li, M.; Liu, Z.T.; Xu, Y.; Cui, Y.B.; Li, D.; Kong, Z.M. Comparative effects of Cd and Pb on biochemical response and DNA damage in the earthworm Eisenia fetida (Annelida, Oligochaeta). Chemosphere 2009, 74(5), 621-625.doi: 10.1016/j.chemosphere.2008.10.048

Professional affiliations

• International Society of Exposure Science
• Society of Environmental Toxicology and Chemistry
• International Society of Industrial Ecology
• American Center for Life Cycle Assessment

Selected publications

• Li, D.; Hicks, A. Navigating through the challenges to reach life cycle sustainability. Integr. Environ. Assess. Manag. 2018 (accepted)
• Tao, M.; Li, D.; Song, R.; Suh, S.; Keller, A.A. Framework for modeling the release of chemicals from the use of consumer products. Environ. Pollut. 2018, 234, 751-761. doi: 10.1016/j.envpol.2017.11.058
• Tsang, M.; Li, D.; Garner, K.L.; Keller, A.A.; Suh, S.; Sonnemann, G.W. Human health impacts of indoor nanomaterial emissions for life cycle assessment: A case study of titanium dioxide. Environ. Sci. Nano. 2017, 4, 1705-1721. doi: 10.1039/C7EN00251C
• Li, D.; Morishita, M.; Wagner, J.G.; Fatouraie, M.; Wooldridge, M.; Eagle, E.; Barres, J.; Carlander, U.; Emond, C.; Jolliet, O. In vitro biodistribution and physiologically based pharmacokinetic modeling of inhaled fresh and aged cerium oxide nanoparticles. Part. Fibre Toxicol. 2016, 13, 45. doi: 10.1186/s12989-016-0156-2
• Carlander, U.; Li, D.; Jolliet, O.; Emond, C.; Johanson, G. Towards a general physiologically based pharmacokinetic (PBPK) model for intravenously injected nanoparticles. Int. J. Nanomed.2016, 11, 625-640. doi: 10.2147/IJN.S94370
• Li, D.; Johanson, G.; Emond, C.; Carlander, U.; Philbert, M.; Jolliet, O. Physiologically based pharmacokinetic modeling of polyethylene glycol-coated polyacrylamide nanoparticle in rats. Nanotoxicology 2014, 8(S1), 128-137. doi: 10.3109/17435390.2013.863406
• Wenger, Y.; Li, D.; Jolliet, O. Indoor intake fraction and surface sorption of air organic compounds for life cycle assessment. Int. J. Life Cycle Ass. 2012, 17(7), 919-931. doi: 10.1007/s11367-012-0420-0
• Rosenbaum, R.; Huijbregts, M.; Henderson, A.; Margni, M.; McKone, T.; van de Meent, D.; Hauschild, M.; Shaked, S.; Li, D.; Gold, L.; Jolliet, O. USEtox human exposure and toxicity factors for comparative assessment of toxic emissions in life cycle analysis: sensitivity to key chemical properties. Int. J. Life Cycle Ass. 2011, 16, 710-727. doi: 10.1007/s11367-011-0316-4

Education

• PhD, Environmental Health Sciences, University of Michigan, Ann Arbor, 2015
• BS, Environment Sciences, Nanjing University, 2009