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Won Yim

Won Yim

Assistant Professor

Summary

Recent advance in genomics are generating tremendous amounts of data. As a result, the field of bioinformatics confronts an unprecedented need to move towards greater interdisciplinary to better interpret and understand these data. The goal of our research is to understand the molecular underpinnings of various plant adaptations to semi-arid and arid environments through genomics-enabled bioinformatics approaches. Our research focuses broadly on comparative genomics and gene expression from the perspectives of genomics, systems biology, and bioinformatics. We propose to undertake integrative approaches that span multiple levels of biological organization from the genome to the metabolome.

The Yim’s lab is worked on plant genomics, studying how genomes are organized and how genome structure affects gene expression, phenotypes, and genomic plasticity. We use of bioinformatics to address questions in plant diversity, with an emphasis on enabling crop improvement efforts though through diversification mechanisms associated with large scale genome duplications, while at the same time maintaining core functions. The major objectives of our lab include developing strategies for increased plant tolerance to harsh environments and increased biomass productivity through understanding the basis of polyploidy and genome conformation in plants.

Our on-going research projects include de novo assembly and analysis of multiple genomes and transcriptomes. We participate in a variety of open source software development projects and in other efforts to facilitate data sharing and improving adherence to standards among groups involved in information resource management in plant biology.

Lastly, our lab seeks to illuminate the processes regulating development, metabolomics, protein structure, evolution analysis and photosynthesis and will enable future attempts to characterize gene function in plants, insects and vertebrates.

Education

B.S. Dongguk University, Seoul, Korea, 2006
M.S. Dongguk University, Seoul, Korea, 2008
Ph.D. Dongguk University, Seoul, Korea, 2012

Publications

Journals

2024

Genome Biology and Evolution, Volume 16, Issue 8, August 2024, evae163,

Haomin Lyu, Won Cheol Yim, Qingyi Yu

C4 photosynthesis has independently evolved over 62 times within 19 angiosperm families. The recurrent evolution of C4 photosynthesis appears to contradict the complex anatomical and biochemical...

2024

Plant Methods 20, 140 (2024)

Haibao Tang, Wenqian Kong, Pheonah Nabukalu, Johnathan S Lomas, Michel Moser, Jisen Zhang, Mengwei Jiang, Xingtan Zhang, Andrew H Paterson, Won Cheol Yim

GRABSEEDS streamlines the plant phenotyping process and is effective in a variety of seed, floral and leaf trait studies for association with agronomic traits and stress conditions. Source code and...

2024

iMeta Volume3, Issue4 August 2024 e211

Haibao Tang, Vivek Krishnakumar, Xiaofei Zeng, Zhougeng Xu, Adam Taranto, Johnathan S Lomas, Yixing Zhang, Yumin Huang, Yibin Wang, Won Cheol Yim, Jisen Zhang, Xingtan Zhang

The JCVI library is a versatile Python-based library that offers a suite of tools that excel across these pillars. Featuring a modular design, the JCVI library provides high-level utilities for tasks...

2024

New Phytologist, 241(1), 471-489

Pucker, B., Walker-Hale, N., Dzurlic, J., Yim, W. C., Cushman, J. C., Crum, A., Yang, Y., & Brockington, S. F.

2024

General and Comparative Endocrinology

Meet Zandawala, Muhammad Bilal Amir, Joel Shin, Won Cheol Yim and Luis Alfonso Yáñez-Guerra

2024

Genome Biology and Evolution, Volume 16, Issue 8, August 2024, evae163

Valentina J Alaasam, Cassandra Hui, Johnathan Lomas, Stephen M Ferguson, Yong Zhang, Won Cheol Yim, Jenny Q Ouyang

We present evidence of tolerance to chronic exposure, persistent behavioral responses lasting 8 weeks post-exposure, and attenuation of responses to re-exposure. Oxidative stress decreased under...

2023

Life science alliance 6

Andrew B Nuss, Johnathan S Lomas, Jeremiah B Reyes, Omar Garcia-Cruz, Wenlong Lei, Arvind Sharma, Michael N Pham, Saransh Beniwal, Mia L Swain, Molly McVicar, Isaac Amankona Hinne, Xingtan Zhang, Won C Yim, Monika Gulia-Nuss

2022

Journal of Experimental Botany, Vol. 73, No. 9 pp. 2889–2904

Santos, P., Busta, L., Yim, W. C., Cahoon, E., Kosma, D.

2022

The Plant Cell, Volume 34, Issue 11, November 2022, Pages 4143–4172

Won Cheol Yim, Mia L Swain, Dongna Ma, Hong An, Kevin A Bird, David D Curdie, Samuel Wang, Hyun Don Ham, Agusto Luzuriaga-Neira, Jay S Kirkwood, Manhoi Hur, Juan K Q Solomon, Jeffrey F Harper, Dylan K Kosma, David Alvarez-Ponce, John C Cushman, Patrick P Edger, Annaliese S Mason, J Chris Pires, Haibao Tang, Xingtan Zhang

Here, we report a chromosome scale 1.31-Gbp genome assembly with 156.9-fold sequencing coverage for B. carinata, completing the reference genomes comprising the classic Triangle of U, a classical...

Characterization of a microbial consortium for improved biological degradation of Opuntia ficus-indica biomass for biofuel production.

2021

Heliyon. 7 (8): e07854. DOI: 10.1016/j.heliyon.2021.e07854

Blair BB, Yim WC, Cushman JC.

2021

Systematic Biology. DOI: 10.1093/sysbio/syaa066. PubMed PMID: 32785686.

Moreles-Briones, D.F., Kadereit, G., Tefarikis, D., Moore, M.J., Smith, S.A., Brockington, S.F., Timoneda, A., Yim, W.C., Cushman, J.C., and Yang, Y.

Membrane profiling by free flow Electrophoresis and SWATH-MS to characterize subcellular compartment proteomes in Mesembryanthemum crystallinum.

2021

International Journal of Molecular Sciences. 22:5020. DOI: 10.3390/ijms22095020.

Guo Q, Liu L, Yim WC, Cushman JC, Barkla BJ.

2021

The Plant Journal, 107(1), 77–99

Z. Wahrenburg, E. Benesch, C. Lowe, J. Jimenez, V. K. R. V., S. Lü, R. Hammerschmidt, D. Douches, W. C. Yim, P. Santos, D. K. Kosma

2020

BioDesign Research, 2020, 1-16.

Yuan, G., Hassan, M. M., Liu, D., Lim, S. D., Yim, W. C., Cushman, J. C., Markel, K., Shih, P. M., Lu, H., Weston, D. J., Chen, J.-G., Tschaplinski, T. J., Tuskan, G. A., Yang, X.

2020

Systematic biology

Morales-Briones, D. F., Kadereit, G., Tefarikis, D. T., Moore, M. J., Smith, S. A., Brockington, S. F., Timoneda, A., Yim, W. C., Cushman, J. C., Yang, Y.

2020

The New phytologist, 227(3), 914-929

Sheehan, H., Feng, T., Walker-Hale, N., Lopez-Nieves, S., Pucker, B., Guo, R., Yim, W. C., et.al.

2020

Algal Research Vol 50, September, 101990

Polle, J. E. W., Calhoun, S., McKie-Krisberg, Z., Prochnik, S., Neofotis, P., Yim, W. C., et.al.

2020

Plant Journal, 103(3), 1049-1072

Lim, S. D., Mayer, J. A., Yim, W. C., Cushman, J. C.

Biology and chemistry of an Umbravirus-like 2989 bp single-stranded RNA as a possible causal agent for Opuntia stunting disease (engrosamiente de cladidios) – A review

2019

Journal of the Professional Association for Cactus Development. 21: 1–31.

Felker P, Bunch R, Russo G, Preston K, Tine JA, Suter B, Mo X, Cushman JC, Yim WC

2019

Front Plant Sci. 2019; 10: 129.

Amin AB, Rathnayake KN, Yim WC, Garcia TM, Wone B, Cushman JC, Wone BWM

2019

New Phytologist. 227: 914–929. DOI: 10.1111/nph.16089.

Sheehan H, Feng T, Walker-Hale N, Lopez-Nieves S, Pucker B, Guo R, Yim WC, Badgami R, Timoneda A, Zhao L, Tiley H, Copetti D, Sanderson MJ, Cushman JC, Moore MJ, Smith SA, Brockington SF

2019

Mitochondrion Volume 46, May 2019, Pages 134-139

Wone BWM, Yim WC, Schutz H, Meek TH, Garland T

Mitochondrial haplotypes have been associated with human and rodent phenotypes, including nonshivering thermogenesis capacity, learning capability, and disease risk. Although the mammalian...

The bracteatus pineapple genome and domestication of clonally propagated crops.

2019

Nature Genetics. 51: 1549–1558 DOI: 10.1038/s41588-019-0506-8.

Chen L-Y, VanBuren R, Paris M, Zhou H, Zhang X, Wai CM, Yan H, Chen S, Along M, Ramakrishnan S, Liao Z, Liu J, Lin J, Yue J, Fatima M, Lin Z, Zhang J, Juang L, Wang H, Hwa T-Y, Kao S-M, Choi JY, Sharma A, Song J, Wang H, Yim WC, Cushman JC, Paull RE, Matsumoto T, Qin Y, Wu Q, Wang J, Yu Q, Wu J, Zhang S, Boches P, Tung C-W, Wang M-L, d’Eckenbrugge GC, Sanewski GM, Purrugganan MD, Schatz MC, Bennetzen JL, Lexer C, Ming R.

2018

Plant Biotechnology Journal 09 March 2018

Lim SD, Yim WC, Liu D, Hu R, Yang X, Cushman JC

2018

Plant Physiology December 2018

Busta L, Yim WC, LaBrant EW, Wang P, Grimes L, Malyszka K, Cushman JC, Santos P, Kosma DK, Cahoon EB

Mitochondrial haplotypes are not associated with mice selectively bred for high voluntary wheel running.

2018

Mitochondrion. doi:10.1016/j.mito.2018.04.002

Wone BWM, Yim WC, Schutz H, Meek TH, Garland Jr T.

An rbcL mRNA binding protein is associated with C3 to C4 evolution and light-induced production of Rubisco in Flaveria.

2017

Journal of Experimental Botany DOI:10.1093/jxb/erx264

Yerramsetty PK, Agar EM, Yim WC, Cushman JC, Berry JO

Divide and Conquer (DC) BLAST: Fast and easy BLAST execution within HPC environments.

2017

PeerJ. 5: e3486.

Yim WC, Cushman JC

2017

Genome Announcements doi:10.1128/genomeA.01105-17

Polle JEW, Barry K, Cushman JC, Schmutz J, Tran D, Hathwaik LT, Yim WC, Jenkins J, McKie-Krisberg Z, Prochnik S, Lindquist S, Dockter R, Adam C, Molina H, Bunkenborg J, Jin ES, Buchheim M, Magnuson J.

Expression of Heat Shock Proteins by Heat Stress in Soybean.

2017

Plant Breed. Biotech. 5(4):344~353 doi:10.9787/PBB.2017.5.4.344

Song K, Yim WC, Lee B-M.

2017

BMC Plant Biol doi: 10.1186/s12870-017-1013-7.

Yobi A, Schlauch KA, Tillett RL, Yim WC, Espinoza C, Wone BWM, Cushman JC, Oliver MJ

Temporal and spatial transcriptomic and microRNA dynamics of CAM photosynthesis in pineapple.

2017

The Plant Journal DOI:10.1111/tpj.13630

Wai CM, VanBuren R, Zhang J, Huang L, Miao W, Edger P, Yim WC, Priest HD, Meyers BC, Mockler T, Smith JAC, Cushman JC, Ming R

The Kalanchoë genome provides insights into convergent evolution and building blocks of crassulacean acid metabolism.

2017

Nature Communications doi:10.1038/s41467-017-01491-7

Yang X, Hu R. Yin H, Jenkins J, Shu S, Tang H, Liu D, Weighill DA, Yim WC, Ha J, Heyduk K, Goodstein D, Gou HB, Moseley R, Fitzek E, Jawdy S, Zhang Z, Xie M, Hartwell J, Grimwood J, Abraham P, Mewalal R, Beltrán J, Boxall S, Denver L, Palla K, Albion R, Garcia T, Mayer J, Lim SD, Wai CM, Peluso P, VanBuren R, De Paoli H, Borland A, Guo H, Chen JG, Muchero W, Yin Y, Jacobson D, Tschaplinski T, Hettich R, Ming R, Winter K, Leebens-Mack K, Smith JAC, Cushman JC, Schmutz J, Tuskan G.

Identification of ice plant (Mesembryanthemum crystallinum L.) microRNAs using RNA-Seq and their putative roles in high salinity responses in seedlings.

2016

Frontiers in Plant ScienceFront Plant Sci. doi: 10.3389/fpls.2016.01143

Chiang C, Yim WC, Sun Y, Ohnishi M, Mimura T, Cushman JC, Yen HE.

The pineapple genome and the evolution of CAM photosynthesis.

2016

Nature Genetics. 47: 1435–1442

Ming R, Van Buren R, Wai CM, Tang H, Schatz MC, Bowers, JE, Lyons E, Wang M-L, Chen J, Biggers E, Zhang J, Huang L, Zhang L, Miao W, Zhang J, Ye Z, Miao C, Lin Z, Wang H, Zhou H, Yim WC, Priest HD, Zheng C, Woodhouse M, Edger PP, Guyot R, Guo H-B, Guo H, Zheng G, Singh R, Sharma A, Min X, Zheng Y, Lee H, Gurtowski J, Sedlazeck F, Harkess A, McKain MR, Liao Z, Fang J, Liu J, Zhang X, Zhang Q, Hu W, Yuan Q, Wang K, Chen L-Y, Shirley N, Lin Y-R, Liu L-Y, Hernandez AG, Wright CL, Bulone V, Tuskan GA